Current R&D situation

 

Having successfully completed a new financing round, HpVac has entered the lead optimization phase.

    Activity/Study

    Status

    Results expected

    Production of recombinant molecule and variant(s)

    Quantities to cover validation phase

    Completed


    Bioequivalence study in animal model and dose response

    Completed


    Preliminary pharmacokinetic study

    Completed


    Lead Validation

    Completed


    Mechanism of action studies

    • Cellular mechanism studies

    Completed


    • Molecular mechanism studies

    Ongoing

    1Q 2022

    • Phenotypic screening

    Ongoing

    1Q 2022

    • Biomarker studies

    Ongoing

    1Q 2022

    Production of novel variants

    Ongoing

    3Q 2021

    Cellular Assays on novel variants

    Ongoing

    3Q 2021

    Pharmacokinetic studies

    Ongoing

    4Q 2021

    Animal model studies

    Early 2022

    1Q 2022

    Completion of Lead Optimization phase


    1Q 2022

    Activity/Study

    Production of recombinant molecule and variant(s)


    Status: Completed

    Quantities cover validation and preclinical studies


    Status: January 2019

    Bioequivalence study in animal models and dose response 


    Status: April 2019

    Results expected: June 2019

    Pharmacokinetics study


    Status: selection of CRO

    Results expected: Q2 2019

    Postdoc study on mechanism of action, UZH


    Status: April 2019

    Results expected: Q3 2019

    License

    GBCHpVac has secured exclusive, worldwide commercialization rights to GBC-R1 from the University of Zurich.

    Intellectual property

    In a first phase, GBC SA has financed the patenting of GBC-R1. See also WO2015/114575 and WO2015/144576.

    Historical

    In the course of her studies on gastric cancer, Prof. Dr. Anne Müller and her team have confirmed that GBC-R1 has a tolerogenic effect sufficient to confer protection against several inflammatory or allergic diseases.

    Anne Muller